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Rapid Whole Genome Sequencing (rWGS)

 

Description

A New Paradigm for Whole Genome Sequencing: High Quality, Affordable WGS Data, for When You Need it Fast.

Our rapid Whole Genome Sequencing (rWGS) service is designed for partners who are working in time critical healthcare or research settings where rapid access to quality whole genome data may be key for the effective medical management of acutely ill patients.

Whole genome sequencing can be applied to human genetics and evolution studies to detect genome-wide genetic variations, pathogenic and susceptibility genes, and to enable genetic diversity and evolution analysis. It can also be applied to translational research to provide information on cancer and disease-associated mutations and is one of the most important approaches of precision medicine.

We provide rWGS with a 10 working day turn around time from acceptance of qualified samples. The service is executed with DNBSEQ™ technology platform for great sequencing data at the lowest cost in the industry.

We currently offer rapid Human Whole Genome Sequencing including:

  • Sample QC, library construction and sequencing 90Gb Data
  • High quality 30X 150PE data delivered in standard FASTQ format
  • Multiple bioinformatics options available

 

DNBSEQ™ NGS technology platform

Human Whole Genome Sequencing services are typically executed with our proprietary DNBSEQ™ NGS technology platform, for great sequencing data at the lowest cost in the industry.

DNBSEQ™ is BGI’s proprietary sequencing technology, developed by Complete Genomics subsidiary in Silicon Valley. This system is powered by combinatorial Probe-Anchor Synthesis (cPAS), linear isothermal Rolling-Circle Replication and DNA Nanoballs (DNB™) technology, followed by high-resolution digital imaging.

 

Data Performance

Routine sequencing quality scores (NA12878, 150PE, 30x) meet or exceed those from current industry-leading sequencing technology: ≥ 95% of bases ≥ Q20 and ≥86% of bases ≥ Q30.

 

Applications

  • Germline Variant Detection.
  • Somatic Variant Detection.
  • Associating DNA Variants with Phenotype (Disease).
  • Structural Variant Discovery (SV Discovery).
  • Copy Number Variation Detection (CNV Detection).
  • Biomarker Discovery.

 

Sample Preparation and Services

  • 150bp paired end sequencing
  • Raw data, standard and customized data analysis
  • CAP/CLIA laboratory services
  • Cloud-based data storage and delivery system Sequencing Quality Standard
  • Guaranteed ≥ 80% of bases with quality score of ≥Q30
  • Standard sequencing coverage ≥30X; ≥60X is recommended for cancer sample

 

Turn Around Time

  • Typical 10 working days from sample QC acceptance to filtered raw data availability
  • Expedited services are available, contact your local BGI specialist for details

 

Sample Requirements

We can process your gDNA, Blood, Cell line, Fresh frozen tissue applications, with the following general requirements:

  • Genomic DNA >1ug (c>12.5ng/ul).
  • Minimum Sample Volume (15 ul).